We followed standard criteria for conducting and reporting of meta-analyses of observational studies ( 9). Therefore, we performed a systematic review and dose-response meta-analysis to assess the association between magnesium intake and risk of total stroke and stroke subtypes. To our knowledge, the epidemiologic evidence on the relation between dietary magnesium intake and risk of stroke has not yet been summarized. Hence, a high dietary magnesium intake may potentially reduce risk of stroke. Furthermore, findings from animal studies have shown that high-magnesium diets have favorable effects on plasma glucose and blood lipid concentrations ( 7), and magnesium deficiency increases the susceptibility of lipoproteins to peroxidation ( 8). Randomized clinical trials have shown that magnesium supplementation modestly reduces diastolic blood pressure ( 5) as well as fasting C-peptide and insulin concentrations ( 6). INTRODUCTIONĭietary magnesium intake has been inversely associated with risk factors for stroke such as hypertension ( 1, 2), metabolic syndrome ( 3), and type 2 diabetes ( 2, 4). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01 95% CI: 0.90, 1.14).Ĭonclusion: Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92 95% CI: 0.88, 0.97), without heterogeneity among studies ( P = 0.66, I 2 = 0%). We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. Results: Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. Results from individual studies were combined by using a random-effects model.
We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Objective: We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk.ĭesign: Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. Background: Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results.
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